A platelet plug stops the bleeding temporarily, but it also represents the base for a blood clot.

It is consisted of thousands of platelets, mechanically patching the injured blood vessel. Hemostasis is divided into four stages, starting with blood vessel narrowing (vasoconstriction), going through platelet plug formation, then blood clotting (coagulation), and finally finishing with stabilization and breakdown of blood clots with a process called fibrinolysis.ДЄ platelet plug is necessary for stopping of bleeding and recovery of vascular injuries, but if it occurs in unwanted location, it leads to thrombosis, a pathological obstruction of blood vessels. Platelet plug aggregation is a part of hemostasis, a process responsible for stopping of bleeding. Platelet plug forming (platelet aggregation)

A number of antiplatelet drugs have been developed and synthesized since then. Later, in the mid 20th century, aspirinвЂ™s true mechanism of action was found and clinical tests have shown that it decreases the risk of diseases related to thrombosis. In 1897, a German scientist Felix Hoffman who was working for Bayer has synthesized aspirin. Acetylsalicylic acid ( aspirin), is a famous drug used since ancient times, and even then it was known that plants which contain salicylate such as willow can reduce the pain and fever. Antiplatelet drugs are widely used to prevent arterial thrombosis in various cardiovascular-related conditions.

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